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Gene: CAPN6 (calpain 6) Homo sapiens
Symbol: CAPN6
Name: calpain 6
Description: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: calpain-6; calpain-like protease X-linked; calpamodulin; CalpM; CANPX; CAPNX; DJ914P14.1
Mus musculus (house mouse) : Capn6 (calpain 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Capn6 (calpain 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Capn6 (calpain 6)
Pan paniscus (bonobo/pygmy chimpanzee) : CAPN6 (calpain 6)
Canis lupus familiaris (dog) : CAPN6 (calpain 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Capn6 (calpain 6)
Sus scrofa (pig) : CAPN6 (calpain 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X111,245,099 - 111,270,546 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X110,488,327 - 110,513,774 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X110,374,987 - 110,400,407 (-)NCBINCBI36hg18NCBI36
Build 34X110,294,475 - 110,319,896NCBI
CeleraX110,967,943 - 110,993,390 (-)NCBI
Cytogenetic MapXq23NCBI
HuRefX100,110,837 - 100,136,321 (-)NCBIHuRef
CHM1_1X110,399,827 - 110,425,289 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CAPN6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734276
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.