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Gene: GATA2 (GATA binding protein 2) Homo sapiens
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Symbol: GATA2
Name: GATA binding protein 2
CRRD ID: 734291
Description: Exhibits several functions, including C2H2 zinc finger domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including negative regulation of cell population proliferation; positive regulation of sprouting angiogenesis; and regulation of gene expression. Localizes to cytoplasm and nucleoplasm. Implicated in acute myeloid leukemia; immunodeficiency 21; mental depression; myelodysplastic syndrome; and myeloid leukemia. Biomarker of acute myeloid leukemia; aplastic anemia; immunodeficiency 21; and myelodysplastic syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DCML; endothelial transcription factor GATA-2; FLJ45948; GATA-binding protein 2; IMD21; MGC2306; MONOMAC; NFE1B
Orthologs:
Mus musculus (house mouse) : Gata2 (GATA binding protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gata2 (GATA binding protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gata2 (GATA binding protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GATA2 (GATA binding protein 2)
Canis lupus familiaris (dog) : GATA2 (GATA binding protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gata2 (GATA binding protein 2)
Sus scrofa (pig) : GATA2 (GATA binding protein 2)
Chlorocebus sabaeus (African green monkey) : GATA2 (GATA binding protein 2)
Heterocephalus glaber (naked mole-rat) : Gata2 (GATA binding protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3128,479,427 - 128,493,201 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl3128,479,427 - 128,493,185 (-)EnsemblGRCh38hg38GRCh38
GRCh383128,479,422 - 128,493,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373128,198,265 - 128,212,030 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363129,680,960 - 129,694,718 (-)NCBINCBI36hg18NCBI36
Build 343129,680,969 - 129,694,726NCBI
Celera3126,626,234 - 126,639,997 (-)NCBI
Cytogenetic Map3q21.3NCBI
HuRef3125,582,307 - 125,596,070 (-)NCBIHuRef
CHM1_13128,161,207 - 128,175,078 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on GATA2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734291
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.