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Gene: SIAH2 (siah E3 ubiquitin protein ligase 2) Homo sapiens
Symbol: SIAH2
Name: siah E3 ubiquitin protein ligase 2
Description: Predicted to have ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; and ubiquitin-dependent protein catabolic process. Localizes to cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E3 ubiquitin-protein ligase SIAH2; hSiah2; RING-type E3 ubiquitin transferase SIAH2; seven in absentia homolog 2; siah-2
Mus musculus (house mouse) : Siah2 (siah E3 ubiquitin protein ligase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Siah2 (siah E3 ubiquitin protein ligase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Siah2 (siah E3 ubiquitin protein ligase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SIAH2 (siah E3 ubiquitin protein ligase 2)
Canis lupus familiaris (dog) : SIAH2 (siah E3 ubiquitin protein ligase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Siah2 (siah E3 ubiquitin protein ligase 2)
Sus scrofa (pig) : SIAH2 (siah E3 ubiquitin protein ligase 2)
Chlorocebus sabaeus (African green monkey) : SIAH2 (siah E3 ubiquitin protein ligase 2)
Heterocephalus glaber (naked mole-rat) : Siah2 (siah E3 ubiquitin protein ligase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl3150,741,125 - 150,763,477 (-)EnsemblGRCh38hg38GRCh38
GRCh383150,741,125 - 150,763,169 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373150,458,910 - 150,481,263 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363151,941,600 - 151,963,953 (-)NCBINCBI36hg18NCBI36
Build 343151,941,608 - 151,963,961NCBI
Celera3148,871,981 - 148,894,332 (-)NCBI
Cytogenetic Map3q25.1NCBI
HuRef3147,832,386 - 147,876,859 (-)NCBIHuRef
CHM1_13150,421,938 - 150,444,291 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SIAH2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734303
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.