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Gene: TGFBR2 (transforming growth factor beta receptor 2) Homo sapiens
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Symbol: TGFBR2
Name: transforming growth factor beta receptor 2
Description: Exhibits several functions, including transforming growth factor beta binding activity; transforming growth factor beta receptor binding activity; and transforming growth factor beta-activated receptor activity. Involved in several processes, including positive regulation of CD4-positive, alpha-beta T cell proliferation; protein phosphorylation; and response to cholesterol. Localizes to several cellular components, including the caveola; external side of plasma membrane; and receptor complex. Implicated in Loeys-Dietz syndrome 2; Marfan syndrome; gastrointestinal system cancer (multiple); hereditary nonpolyposis colorectal cancer type 6; and pancreatic cancer. Biomarker of arteriosclerosis; pancreatic cancer; pancreatic ductal carcinoma; and vasculogenic impotence.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; tbetaR-II; TBR-ii; TBRII; TGF-beta receptor type II; TGF-beta receptor type IIB; TGF-beta receptor type-2; TGF-beta type II receptor; TGFbeta-RII; TGFR-2; transforming growth factor beta receptor II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor ii; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II (70/80kDa) isoform 1; transforming growth factor, beta receptor II (70/80kDa) isoform 2; transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II epsilon; transforming growth factor, beta receptor II gamma; transforming growth factor-beta receptor type II
Orthologs:
Mus musculus (house mouse) : Tgfbr2 (transforming growth factor, beta receptor II)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tgfbr2 (transforming growth factor, beta receptor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgfbr2 (transforming growth factor beta receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TGFBR2 (transforming growth factor beta receptor 2)
Canis lupus familiaris (dog) : TGFBR2 (transforming growth factor beta receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgfbr2 (transforming growth factor beta receptor 2)
Sus scrofa (pig) : TGFBR2 (transforming growth factor beta receptor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38330,606,472 - 30,694,142 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37330,647,994 - 30,735,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36330,622,998 - 30,710,638 (+)NCBINCBI36hg18NCBI36
Build 34330,623,041 - 30,708,147NCBI
Celera330,584,920 - 30,672,564 (+)NCBI
Cytogenetic Map3p24.1NCBI
HuRef330,590,599 - 30,678,240 (+)NCBIHuRef
CHM1_1330,598,177 - 30,685,783 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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