Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Myoc (myocilin) Mus musculus
Analyze
Symbol: Myoc
Name: myocilin
Description: Exhibits receptor tyrosine kinase binding activity. Involved in several processes, including ERBB2-ERBB3 signaling pathway; neurogenesis; and skeletal muscle hypertrophy. Localizes to several cellular components, including Golgi apparatus; endoplasmic reticulum; and node of Ranvier. Used to study open-angle glaucoma. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Is expressed in several structures, including brain; eye; genitourinary system; lung; and meninges. Orthologous to human MYOC (myocilin); INTERACTS WITH benzo[a]pyrene; bisphenol A; ciguatoxin CTX1B.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI957332; GLC1A; MGC159032; TIGR; trabecular meshwork-induced glucocorticoid response protein
Orthologs:
Homo sapiens (human) : MYOC (myocilin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Myoc (myocilin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myoc (myocilin)
Pan paniscus (bonobo/pygmy chimpanzee) : MYOC (myocilin)
Canis lupus familiaris (dog) : MYOC (myocilin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myoc (myocilin)
Sus scrofa (pig) : MYOC (myocilin)
Chlorocebus sabaeus (African green monkey) : MYOC (myocilin)
Heterocephalus glaber (naked mole-rat) : Myoc (myocilin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1162,639,155 - 162,649,693 (+)EnsemblGRCm38mm10GRCm38
GRCm381162,639,150 - 162,649,694 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371164,569,281 - 164,579,825 (+)NCBIGRCm37mm9NCBIm37
MGSCv361164,475,844 - 164,486,368 (+)NCBImm8
Celera1165,085,895 - 165,096,434 (+)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Myoc
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734341
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.