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Gene: Myoc (myocilin) Mus musculus
Symbol: Myoc
Name: myocilin
Description: Exhibits receptor tyrosine kinase binding activity. Involved in several processes, including ERBB2-ERBB3 signaling pathway; neurogenesis; and skeletal muscle hypertrophy. Localizes to several cellular components, including Golgi apparatus; endoplasmic reticulum; and node of Ranvier. Used to study open-angle glaucoma. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Is expressed in several structures, including brain; eye; genitourinary system; lung; and meninges. Orthologous to human MYOC (myocilin); INTERACTS WITH benzo[a]pyrene; bisphenol A; ciguatoxin CTX1B.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI957332; GLC1A; MGC159032; TIGR; trabecular meshwork-induced glucocorticoid response protein
Homo sapiens (human) : MYOC (myocilin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Myoc (myocilin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myoc (myocilin)
Pan paniscus (bonobo/pygmy chimpanzee) : MYOC (myocilin)
Canis lupus familiaris (dog) : MYOC (myocilin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myoc (myocilin)
Sus scrofa (pig) : MYOC (myocilin)
Chlorocebus sabaeus (African green monkey) : MYOC (myocilin)
Heterocephalus glaber (naked mole-rat) : Myoc (myocilin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1162,639,155 - 162,649,693 (+)EnsemblGRCm38mm10GRCm38
GRCm381162,639,150 - 162,649,694 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371164,569,281 - 164,579,825 (+)NCBIGRCm37mm9NCBIm37
MGSCv361164,475,844 - 164,486,368 (+)NCBImm8
Celera1165,085,895 - 165,096,434 (+)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Myoc
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734341
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.