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Gene: JUN (Jun proto-oncogene, AP-1 transcription factor subunit) Homo sapiens
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Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in several processes, including regulation of transcription, DNA-templated; regulation of viral transcription; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to the nuclear euchromatin; nucleoplasm; and transcription factor AP-1 complex. Implicated in pulmonary tuberculosis. Biomarker of Hodgkin's lymphoma; breast cancer; carcinoma (multiple); and colorectal adenoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activator protein 1; AP-1; AP1; c-Jun; cJUN; enhancer-binding protein AP1; Jun activation domain binding protein; jun oncogene; jun proto-oncogene; p39; proto-oncogene c-Jun; proto-oncogene cJun; transcription factor AP-1; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog
Orthologs:
Mus musculus (house mouse) : Jun (jun proto-oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Jun (Jun proto-oncogene, AP-1 transcription factor subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jun (Jun proto-oncogene, AP-1 transcription factor subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : JUN (Jun proto-oncogene, AP-1 transcription factor subunit)
Canis lupus familiaris (dog) : JUN (Jun proto-oncogene, AP-1 transcription factor subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jun (Jun proto-oncogene, AP-1 transcription factor subunit)
Sus scrofa (pig) : JUN (Jun proto-oncogene, AP-1 transcription factor subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38158,780,791 - 58,784,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37159,246,463 - 59,249,785 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36159,019,051 - 59,022,373 (-)NCBINCBI36hg18NCBI36
Build 34158,958,483 - 58,961,806NCBI
Celera157,530,296 - 57,533,618 (-)NCBI
Cytogenetic Map1p32.1NCBI
HuRef157,356,787 - 57,360,109 (-)NCBIHuRef
CHM1_1159,361,828 - 59,365,150 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations