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Gene: XPNPEP2 (X-prolyl aminopeptidase 2) Homo sapiens
Symbol: XPNPEP2
Name: X-prolyl aminopeptidase 2
Description: Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AEACEI; aminoacylproline aminopeptidase; APP2; mAmP; membrane-bound aminopeptidase P; membrane-bound AmP; membrane-bound APP; X-Pro aminopeptidase 2; X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound; xaa-Pro aminopeptidase 2
Mus musculus (house mouse) : Xpnpep2 (X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound)  MGI  Alliance
Rattus norvegicus (Norway rat) : Xpnpep2 (X-prolyl aminopeptidase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xpnpep2 (X-prolyl aminopeptidase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : XPNPEP2 (X-prolyl aminopeptidase 2)
Canis lupus familiaris (dog) : XPNPEP2 (X-prolyl aminopeptidase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xpnpep2 (X-prolyl aminopeptidase 2)
Sus scrofa (pig) : XPNPEP2 (X-prolyl aminopeptidase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X129,738,970 - 129,769,549 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X128,872,946 - 128,903,525 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X128,700,627 - 128,731,206 (+)NCBINCBI36hg18NCBI36
Build 34X128,598,460 - 128,629,060NCBI
CeleraX129,259,509 - 129,290,027 (+)NCBI
Cytogenetic MapXq26.1NCBI
HuRefX118,278,391 - 118,304,600 (+)NCBIHuRef
CHM1_1X128,784,288 - 128,814,871 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on XPNPEP2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734376
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.