Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: ATP5F1A (ATP synthase F1 subunit alpha) Homo sapiens
Analyze
Symbol: ATP5F1A
Name: ATP synthase F1 subunit alpha
Description: Exhibits MHC class I protein binding activity; angiostatin binding activity; and proton-transporting ATP synthase activity, rotational mechanism. Contributes to ATPase activity. Involved in ATP biosynthetic process; negative regulation of endothelial cell proliferation; and positive regulation of blood vessel endothelial cell migration. Localizes to the mitochondrial proton-transporting ATP synthase complex and plasma membrane. Colocalizes with the COP9 signalosome. Implicated in combined oxidative phosphorylation deficiency and mitochondrial complex V (ATP synthase) deficiency nuclear type 4. Biomarker of vascular dementia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP synthase alpha chain, mitochondrial; ATP synthase subunit alpha, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non-cardiac muscle-like 2; ATP sythase (F1-ATPase) alpha subunit; ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22; epididymis secretory sperm binding protein Li 123m; hATP1; HEL-S-123m; MC5DN4; mitochondrial ATP synthetase, oligomycin-resistant; mitochondrial h+-atp synthase alpha subunit; MOM2; OMR; ORM
Orthologs:
Mus musculus (house mouse) : Atp5a1 (ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Atp5f1a (ATP synthase F1 subunit alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp5f1a (ATP synthase F1 subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP5F1A (ATP synthase F1 subunit alpha)
Canis lupus familiaris (dog) : ATP5F1A (ATP synthase F1 subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp5f1a (ATP synthase F1 subunit alpha)
Sus scrofa (pig) : ATP5F1A (ATP synthase F1 subunit alpha)
Chlorocebus sabaeus (African green monkey) : ATP5F1A (ATP synthase F1 subunit alpha)
Heterocephalus glaber (naked mole-rat) : Atp5f1a (ATP synthase F1 subunit alpha)
more info ...
Related Pseudogenes: ATP5F1AP1   ATP5F1AP10   ATP5F1AP2   ATP5F1AP3   ATP5F1AP4   ATP5F1AP7   ATP5F1AP8  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1846,080,248 - 46,104,334 (-)EnsemblGRCh38hg38GRCh38
GRCh381846,080,248 - 46,104,233 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371843,664,110 - 43,684,199 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361841,918,108 - 41,938,197 (-)NCBINCBI36hg18NCBI36
Build 341841,918,107 - 41,932,285NCBI
Celera1840,472,298 - 40,486,450 (-)NCBI
Cytogenetic Map18q21.1NCBI
HuRef1840,521,726 - 40,541,788 (-)NCBIHuRef
CHM1_11843,591,321 - 43,611,335 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ATP5F1A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734400
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.