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Gene: CTSB (cathepsin B) Homo sapiens
Symbol: CTSB
Name: cathepsin B
CRRD ID: 734437
Description: Exhibits collagen binding activity; cysteine-type endopeptidase activity; and proteoglycan binding activity. Involved in several processes, including cellular response to thyroid hormone stimulus; collagen catabolic process; and proteolysis involved in cellular protein catabolic process. Localizes to several cellular components, including lysosome; nucleolus; and perinuclear region of cytoplasm. Implicated in diabetes mellitus. Biomarker of several diseases, including autoimmune disease of the nervous system (multiple); esophagus adenocarcinoma; glioblastoma multiforme; intracranial aneurysm; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: amyloid precursor protein secretase; APP secretase; APPS; cathepsin B1; CPSB; cysteine protease; RECEUP
Mus musculus (house mouse) : Ctsb (cathepsin B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ctsb (cathepsin B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ctsb (cathepsin B)
Pan paniscus (bonobo/pygmy chimpanzee) : CTSB (cathepsin B)
Canis lupus familiaris (dog) : CTSB (cathepsin B)
Sus scrofa (pig) : CTSB (cathepsin B)
Chlorocebus sabaeus (African green monkey) : CTSB (cathepsin B)
Heterocephalus glaber (naked mole-rat) : Ctsb (cathepsin B)
more info ...
Related Pseudogenes: AL627308.1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl811,842,524 - 11,869,448 (-)EnsemblGRCh38hg38GRCh38
GRCh38811,842,524 - 11,868,087 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37811,700,033 - 11,725,646 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36811,737,442 - 11,763,055 (-)NCBINCBI36hg18NCBI36
Build 34811,739,235 - 11,763,044NCBI
Celera810,829,316 - 10,854,967 (-)NCBI
Cytogenetic Map8p23.1NCBI
HuRef810,630,970 - 10,656,616 (-)NCBIHuRef
CHM1_1811,765,442 - 11,791,103 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CTSB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734437
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.