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Gene: Ppm1e (protein phosphatase, Mg2+/Mn2+ dependent, 1E) Rattus norvegicus
Symbol: Ppm1e
Name: protein phosphatase, Mg2+/Mn2+ dependent, 1E
Description: Exhibits protein serine/threonine phosphatase activity. Predicted to be involved in several processes, including negative regulation of protein kinase activity; peptidyl-threonine dephosphorylation; and positive regulation of stress fiber assembly. Localizes to the mitochondrion and nucleus. Orthologous to human PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH ammonium chloride; atrazine; bisphenol A.
Type: protein-coding
Also known as: ca(2+)/calmodulin-dependent protein kinase phosphatase N; calmodulin-dependent protein kinase phosphatase N; caMKN; caMKP-N; caMKP-nucleus; partner of PIX 1; partner of PIX-alpha; partner of PIXA; protein phosphatase 1E; protein phosphatase 1E (PP2C domain containing)
Homo sapiens (human) : PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E)  HGNC  Alliance
Mus musculus (house mouse) : Ppm1e (protein phosphatase 1E (PP2C domain containing))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppm1e (protein phosphatase, Mg2+/Mn2+ dependent 1E)
Pan paniscus (bonobo/pygmy chimpanzee) : PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E)
Canis lupus familiaris (dog) : PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppm1e (protein phosphatase, Mg2+/Mn2+ dependent 1E)
Sus scrofa (pig) : PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01074,548,270 - 74,679,858 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01075,421,043 - 75,552,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41075,516,706 - 75,674,452 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11075,531,075 - 75,688,822 (-)NCBI
Celera1070,971,343 - 71,103,804 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Ppm1e
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735028
Created: 2004-02-05
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.