Gene: Nedd4l (neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase) Rattus norvegicus
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Symbol: Nedd4l
Name: neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Description: Exhibits potassium channel inhibitor activity and ubiquitin-protein transferase activity; involved in several processes, including negative regulation of potassium ion transmembrane transporter activity, positive regulation of caveolin-mediated endocytosis, and positive regulation of protein catabolic process; predicted to colocalize with the plasma membrane; orthologous to human NEDD4L (neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; aldosterone signaling pathway; endocytosis pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E3 ubiquitin-protein ligase NEDD4-like; MGC105877; Nedd4-2; neural precursor cell expressed, developmentally down-regulated 4-like; neural precursor cell expressed, developmentally down-regulated gene 4-like
Orthologs:
Homo sapiens (human) : NEDD4L (NEDD4 like E3 ubiquitin protein ligase)  HGNC  Alliance
Mus musculus (house mouse) : Nedd4l (neural precursor cell expressed, developmentally down-regulated gene 4-like)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nedd4l (NEDD4 like E3 ubiquitin protein ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : NEDD4L (NEDD4 like E3 ubiquitin protein ligase)
Canis lupus familiaris (dog) : NEDD4L (NEDD4 like E3 ubiquitin protein ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nedd4l (NEDD4 like E3 ubiquitin protein ligase)
Sus scrofa (pig) : NEDD4L (NEDD4 like E3 ubiquitin protein ligase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01860,392,376 - 60,719,720 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01859,595,643 - 59,921,504 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41861,134,242 - 61,477,040 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11861,528,414 - 61,549,290 (+)NCBI
Celera1856,529,040 - 56,853,871 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Nedd4l
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735047
Created: 2004-02-05
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.