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Gene: Dld (dihydrolipoamide dehydrogenase) Rattus norvegicus
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Symbol: Dld
Name: dihydrolipoamide dehydrogenase
Description: Exhibits coenzyme binding activity; dihydrolipoyl dehydrogenase activity; and lipoamide binding activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Involved in aging; carboxylic acid metabolic process; and dihydrolipoamide metabolic process. Localizes to the mitochondrion; oxoglutarate dehydrogenase complex; and pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DLD (dihydrolipoamide dehydrogenase); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; INTERACTS WITH (R)-lipoic acid; 1,3-dinitrobenzene; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex); dihydrolipoyl dehydrogenase, mitochondrial
Orthologs:
Homo sapiens (human) : DLD (dihydrolipoamide dehydrogenase)  HGNC  Alliance
Mus musculus (house mouse) : Dld (dihydrolipoamide dehydrogenase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dld (dihydrolipoamide dehydrogenase)
Pan paniscus (bonobo/pygmy chimpanzee) : DLD (dihydrolipoamide dehydrogenase)
Canis lupus familiaris (dog) : DLD (dihydrolipoamide dehydrogenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dld (dihydrolipoamide dehydrogenase)
Sus scrofa (pig) : DLD (dihydrolipoamide dehydrogenase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0650,597,677 - 50,618,694 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0659,273,427 - 59,293,925 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4649,185,188 - 49,205,894 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1649,188,314 - 49,209,020 (-)NCBI
Celera647,106,161 - 47,126,575 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Dld
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735073
Created: 2004-02-05
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.