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Gene: Pde8a (phosphodiesterase 8A) Rattus norvegicus
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Symbol: Pde8a
Name: phosphodiesterase 8A
Description: Predicted to have 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and kinase binding activity. Predicted to be involved in cellular response to epidermal growth factor stimulus; negative regulation of hydrogen peroxide-induced cell death; and positive regulation of ERK1 and ERK2 cascade. Orthologous to human PDE8A (phosphodiesterase 8A); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cAMP-specific cyclic nucleotide phosphodiesterase PDE8; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; RNPDE8A
Orthologs:
Homo sapiens (human) : PDE8A (phosphodiesterase 8A)  HGNC  Alliance
Mus musculus (house mouse) : Pde8a (phosphodiesterase 8A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde8a (phosphodiesterase 8A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE8A (phosphodiesterase 8A)
Canis lupus familiaris (dog) : PDE8A (phosphodiesterase 8A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde8a (phosphodiesterase 8A)
Sus scrofa (pig) : PDE8A (phosphodiesterase 8A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01143,036,083 - 143,160,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,036,218 - 143,159,433 (+)Ensembl
Rnor_5.01143,980,312 - 144,102,752 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,415,852 - 137,544,337 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11137,494,257 - 137,622,743 (+)NCBI
Celera1127,217,639 - 127,339,111 (+)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Pde8a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735125
Created: 2004-02-05
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.