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Gene: Slc4a8 (solute carrier family 4 member 8) Rattus norvegicus
Symbol: Slc4a8
Name: solute carrier family 4 member 8
CRRD ID: 735164
Description: Predicted to have chloride transmembrane transporter activity and sodium:bicarbonate symporter activity. Predicted to be involved in several processes, including bicarbonate transport; inorganic ion transmembrane transport; and positive regulation of synaptic vesicle exocytosis. Localizes to several cellular components, including axon; glutamatergic synapse; and synaptic vesicle. Biomarker of prediabetes syndrome. Orthologous to human SLC4A8 (solute carrier family 4 member 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: electroneutral Na+-driven Cl-HCO3 exchanger; electroneutral sodium bicarbonate exchanger 1; k-NBC3; LOC315311; Na-driven Cl-HCO3 exchanger NDCBE1-A; Na-driven Cl-HCO3 exchanger NDCBE1-B; Na-driven Cl-HCO3 exchanger NDCBE1-C; solute carrier family 4 (anion exchanger), member 8; solute carrier family 4, sodium bicarbonate cotransporter, member 8
Homo sapiens (human) : SLC4A8 (solute carrier family 4 member 8)  HGNC  Alliance
Mus musculus (house mouse) : Slc4a8 (solute carrier family 4 (anion exchanger), member 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc4a8 (solute carrier family 4 member 8)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC4A8 (solute carrier family 4 member 8)
Canis lupus familiaris (dog) : SLC4A8 (solute carrier family 4 member 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc4a8 (solute carrier family 4 member 8)
Sus scrofa (pig) : SLC4A8 (solute carrier family 4 member 8)
Chlorocebus sabaeus (African green monkey) : SLC4A8 (solute carrier family 4 member 8)
Heterocephalus glaber (naked mole-rat) : Slc4a8 (solute carrier family 4 member 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07142,397,352 - 142,467,398 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,397,371 - 142,464,158 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,201,544 - 140,271,679 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,230,085 - 139,575,631 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17139,306,521 - 139,652,068 (+)NCBI
Celera7128,340,100 - 128,399,333 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Slc4a8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735164
Created: 2004-02-05
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.