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Gene: GPR37 (G protein-coupled receptor 37) Homo sapiens
Symbol: GPR37
Name: G protein-coupled receptor 37
Description: Exhibits several functions, including G protein-coupled receptor activity; Hsp70 protein binding activity; and ubiquitin protein ligase binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and positive regulation of MAPK cascade. Localizes to several cellular components, including the endoplasmic reticulum; receptor complex; and ubiquitin ligase complex. Biomarker of Lewy body dementia and Parkinson's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EDNRBL; endothelin B receptor-like protein 1; endothelin receptor type B-like; ETBR-LP-1; G protein-coupled receptor 37 (endothelin receptor type B-like); G-protein coupled receptor 37; hET(B)R-LP; PAELR; Parkin-associated endothelin receptor-like receptor; probable G-protein coupled receptor 37; prosaposin receptor GPR37
Mus musculus (house mouse) : Gpr37 (G protein-coupled receptor 37)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpr37 (G protein-coupled receptor 37)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpr37 (G protein-coupled receptor 37)
Pan paniscus (bonobo/pygmy chimpanzee) : GPR37 (G protein-coupled receptor 37)
Canis lupus familiaris (dog) : GPR37 (G protein-coupled receptor 37)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpr37 (G protein-coupled receptor 37)
Sus scrofa (pig) : GPR37 (G protein-coupled receptor 37)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh387124,743,885 - 124,765,792 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377124,385,655 - 124,406,079 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367124,173,350 - 124,192,917 (-)NCBINCBI36hg18NCBI36
Build 347123,980,066 - 123,999,632NCBI
Celera7119,191,362 - 119,210,932 (-)NCBI
Cytogenetic Map7q31.33NCBI
HuRef7118,750,711 - 118,771,098 (-)NCBIHuRef
CHM1_17124,318,797 - 124,339,217 (-)NCBICHM1_1
CRA_TCAGchr7v27123,775,046 - 123,795,470 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GPR37
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735262
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.