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Gene: RET (ret proto-oncogene) Homo sapiens
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Symbol: RET
Name: ret proto-oncogene
Description: Exhibits calcium ion binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including cellular response to retinoic acid; neuron cell-cell adhesion; and positive regulation of signal transduction. Localizes to several cellular components, including the endosome membrane; integral component of plasma membrane; and receptor complex. Implicated in several diseases, including Hirschsprung's disease; congenital central hypoventilation syndrome; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; and multiple endocrine neoplasia type 2B. Biomarker of pancreatic cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cadherin family member 12; cadherin-related family member 16; CDHF12; CDHR16; CUX1/RET fusion; HSCR1; hydroxyaryl-protein kinase; MEN2A; MEN2B; MTC1; proto-oncogene c-Ret; proto-oncogene tyrosine-protein kinase receptor Ret; PTC; rearranged during transfection; receptor tyrosine kinase; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); RET receptor tyrosine kinase; RET transforming sequence; RET-ELE1; RET51
Orthologs:
Mus musculus (house mouse) : Ret (ret proto-oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ret (ret proto-oncogene)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ret (ret proto-oncogene)
Pan paniscus (bonobo/pygmy chimpanzee) : RET (ret proto-oncogene)
Canis lupus familiaris (dog) : RET (ret proto-oncogene)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ret (ret proto-oncogene)
Sus scrofa (pig) : RET (ret proto-oncogene)
Chlorocebus sabaeus (African green monkey) : RET (ret proto-oncogene)
Heterocephalus glaber (naked mole-rat) : Ret (ret proto-oncogene)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1043,077,064 - 43,130,351 (+)Ensembl
GRCh381043,077,027 - 43,130,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371043,572,517 - 43,625,799 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361042,892,523 - 42,945,805 (+)NCBINCBI36hg18NCBI36
Build 341042,892,532 - 42,944,955NCBI
Celera1039,575,663 - 39,628,954 (+)NCBI
Cytogenetic Map10q11.21NCBI
HuRef1040,098,756 - 40,151,896 (+)NCBIHuRef
CHM1_11043,611,715 - 43,665,000 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model