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Gene: GSS (glutathione synthetase) Homo sapiens
Symbol: GSS
Name: glutathione synthetase
Description: Exhibits anion binding activity; magnesium ion binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including cellular amino acid metabolic process; glutathione biosynthetic process; and response to oxidative stress. Localizes to the extracellular exosome. Implicated in Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: epididymis secretory sperm binding protein Li 64p; epididymis secretory sperm binding protein Li 88n; glutathione synthase; GSH synthetase; GSH-S; GSHS; HEL-S-64p; HEL-S-88n; MGC14098
Mus musculus (house mouse) : Gss (glutathione synthetase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gss (glutathione synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gss (glutathione synthetase)
Pan paniscus (bonobo/pygmy chimpanzee) : GSS (glutathione synthetase)
Canis lupus familiaris (dog) : GSS (glutathione synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gss (glutathione synthetase)
Sus scrofa (pig) : GSS (glutathione synthetase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382034,928,432 - 34,956,027 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372033,516,236 - 33,543,794 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,979,897 - 33,007,262 (-)NCBINCBI36hg18NCBI36
Build 342032,979,897 - 33,007,262NCBI
Celera2030,265,329 - 30,292,695 (-)NCBI
Cytogenetic Map20q11.22NCBI
HuRef2030,294,556 - 30,321,979 (-)NCBIHuRef
CHM1_12033,417,456 - 33,445,055 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GSS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735330
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.