Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CDKN1A (cyclin dependent kinase inhibitor 1A) Homo sapiens
Analyze
Symbol: CDKN1A
Name: cyclin dependent kinase inhibitor 1A
Description: Exhibits enzyme binding activity and protein kinase regulator activity. Involved in several processes, including intracellular signal transduction; mitotic cell cycle phase transition; and regulation of protein kinase activity. Localizes to the cyclin-dependent protein kinase holoenzyme complex and nucleus. Implicated in malignant glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Biomarker of several diseases, including Barrett's esophagus; Fuchs' endothelial dystrophy; acoustic neuroma; carcinoma (multiple); and papilloma (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAP20; CDK-interacting protein 1; CDK-interaction protein 1; CDKN1; CIP1; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1a; cyclin-dependent kinase inhibitor 1A (p21, Cip1); DNA synthesis inhibitor; MDA-6; melanoma differentiation associated protein 6; melanoma differentiation-associated protein 6; P21; p21CIP1; p21Cip1/Waf1; SDI1; WAF1; wild-type p53-activated fragment 1
Orthologs:
Mus musculus (house mouse) : Cdkn1a (cyclin-dependent kinase inhibitor 1A (P21))  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdkn1a (cyclin-dependent kinase inhibitor 1A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdkn1a (cyclin dependent kinase inhibitor 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : CDKN1A (cyclin dependent kinase inhibitor 1A)
Canis lupus familiaris (dog) : CDKN1A (cyclin dependent kinase inhibitor 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdkn1a (cyclin dependent kinase inhibitor 1A)
Sus scrofa (pig) : CDKN1A (cyclin dependent kinase inhibitor 1A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38636,676,250 - 36,687,339 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37636,644,237 - 36,655,116 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,754,465 - 36,763,087 (+)NCBINCBI36hg18NCBI36
Build 34636,754,464 - 36,763,086NCBI
Celera638,201,500 - 38,210,146 (+)NCBI
Cytogenetic Map6p21.2NCBI
HuRef636,362,600 - 36,373,330 (+)NCBIHuRef
CHM1_1636,645,994 - 36,657,029 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations