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Gene: TRB (T cell receptor beta locus) Homo sapiens
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Symbol: TRB
Name: T cell receptor beta locus
Description: T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: T-cell antigen receptor, beta polypeptide, T-cell receptor, beta cluster; t-cell receptor beta chain; T-cell receptor beta locus; T-cell receptor, beta cluster; TCRB; TCRB, TRB@; TRB@
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387142,299,011 - 142,813,287 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377141,998,851 - 142,510,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367141,645,314 - 142,221,097 (+)NCBINCBI36hg18NCBI36
Celera7136,776,319 - 137,348,274 (+)NCBI
Cytogenetic Map7q34NCBI
HuRef7136,293,581 - 136,849,278 (+)NCBIHuRef
CHM1_17141,932,983 - 142,447,259 (+)NCBICHM1_1
CRA_TCAGchr7v27141,337,044 - 141,912,827 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
References - curated
References - uncurated

Genomics

Position Markers

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TRB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735360
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.