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Gene: CMA1 (chymase 1) Homo sapiens
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Symbol: CMA1
Name: chymase 1
Description: Exhibits serine-type endopeptidase activity. Involved in basement membrane disassembly and interleukin-1 beta biosynthetic process. Localizes to the secretory granule. Implicated in asthma; atopic dermatitis; hypertrophic cardiomyopathy; and sarcoidosis. Biomarker of asthma; chronic obstructive pulmonary disease; congenital heart disease; and interstitial lung disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha-chymase; chymase; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I; chymase 1, mast cell; chymase, heart; chymase, mast cell; CYH; mast cell protease I; MCT1; MGC119890; MGC119891
Orthologs:
Mus musculus (house mouse) : Cma1 (chymase 1, mast cell)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cma1 (chymase 1)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CMA1 (chymase 1)
Canis lupus familiaris (dog) : CMA1 (chymase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1424,505,353 - 24,508,265 (-)Ensembl
GRCh381424,505,353 - 24,508,265 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371424,974,712 - 24,977,471 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361424,044,552 - 24,047,311 (-)NCBINCBI36hg18NCBI36
Build 341424,044,551 - 24,047,311NCBI
Celera144,839,478 - 4,842,237 (-)NCBI
Cytogenetic Map14q12NCBI
HuRef145,089,481 - 5,092,240 (-)NCBIHuRef
CHM1_11424,973,423 - 24,976,333 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
Related Rat Strains
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CMA1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735367
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.