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Gene: BMPR2 (bone morphogenetic protein receptor type 2) Homo sapiens
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Symbol: BMPR2
Name: bone morphogenetic protein receptor type 2
CRRD ID: 735373
Description: Exhibits BMP binding activity; cadherin binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including positive regulation of ossification; positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and regulation of blood pressure. Localizes to adherens junction; integral component of plasma membrane; and nucleoplasm. Colocalizes with caveola. Implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease. Biomarker of asthma and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BMP type II receptor; BMP type-2 receptor; BMPR-2; BMPR-II; BMPR3; BMR2; bone morphogenetic protein receptor type II; bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type ii (serine/threonine kinase); BRK-3; FLJ41585; FLJ76945; POVD1; PPH1; primary pulmonary hypertension 1; T-ALK; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4
Orthologs:
Mus musculus (house mouse) : Bmpr2 (bone morphogenetic protein receptor, type II (serine/threonine kinase))  MGI  Alliance
Rattus norvegicus (Norway rat) : Bmpr2 (bone morphogenetic protein receptor type 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bmpr2 (bone morphogenetic protein receptor type 2)
Pan paniscus (bonobo/pygmy chimpanzee) : BMPR2 (bone morphogenetic protein receptor type 2)
Canis lupus familiaris (dog) : BMPR2 (bone morphogenetic protein receptor type 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bmpr2 (bone morphogenetic protein receptor type 2)
Sus scrofa (pig) : BMPR2 (bone morphogenetic protein receptor type 2)
Chlorocebus sabaeus (African green monkey) : BMPR2 (bone morphogenetic protein receptor type 2)
Heterocephalus glaber (naked mole-rat) : Bmpr2 (bone morphogenetic protein receptor type 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2202,376,327 - 202,567,751 (+)EnsemblGRCh38hg38GRCh38
GRCh382202,376,310 - 202,567,751 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372203,241,033 - 203,432,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362202,949,916 - 203,140,719 (+)NCBINCBI36hg18NCBI36
Build 342203,067,104 - 203,257,979NCBI
Celera2196,992,827 - 197,184,404 (+)NCBI
Cytogenetic Map2q33.1-q33.2NCBI
HuRef2195,088,272 - 195,279,312 (+)NCBIHuRef
CHM1_12203,247,530 - 203,439,226 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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