Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CDK6 (cyclin dependent kinase 6) Homo sapiens
Symbol: CDK6
Name: cyclin dependent kinase 6
Description: Exhibits several functions, including ATP binding activity; FBXO family protein binding activity; and cyclin binding activity. Involved in several processes, including negative regulation of cellular senescence; regulation of myeloid cell differentiation; and type B pancreatic cell development. Localizes to several cellular components, including the centrosome; cyclin-dependent protein kinase holoenzyme complex; and ruffle. Implicated in lung non-small cell carcinoma; malignant glioma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Biomarker of lung cancer (multiple); malignant glioma (multiple); medulloblastoma; and non-functioning pancreatic endocrine tumor.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cell division protein kinase 6; cyclin-dependent kinase 6; MCPH12; MGC59692; PLSTIRE; serine/threonine-protein kinase PLSTIRE
Mus musculus (house mouse) : Cdk6 (cyclin-dependent kinase 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdk6 (cyclin-dependent kinase 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk6 (cyclin dependent kinase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK6 (cyclin dependent kinase 6)
Canis lupus familiaris (dog) : CDK6 (cyclin dependent kinase 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk6 (cyclin dependent kinase 6)
Sus scrofa (pig) : CDK6 (cyclin dependent kinase 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38792,604,921 - 92,836,627 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37792,234,235 - 92,465,941 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36792,072,171 - 92,301,148 (-)NCBINCBI36hg18NCBI36
Build 34791,878,887 - 92,107,863NCBI
Celera786,938,762 - 87,170,471 (-)NCBI
Cytogenetic Map7q21.2NCBI
HuRef786,843,599 - 87,075,188 (-)NCBIHuRef
CHM1_1792,164,273 - 92,395,977 (-)NCBICHM1_1
CRA_TCAGchr7v2791,563,451 - 91,795,159 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CDK6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735400
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.