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Gene: CDK6 (cyclin dependent kinase 6) Homo sapiens
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Symbol: CDK6
Name: cyclin dependent kinase 6
Description: Exhibits several functions, including ATP binding activity; FBXO family protein binding activity; and cyclin binding activity. Involved in several processes, including negative regulation of cellular senescence; regulation of myeloid cell differentiation; and type B pancreatic cell development. Localizes to several cellular components, including the centrosome; cyclin-dependent protein kinase holoenzyme complex; and ruffle. Implicated in lung non-small cell carcinoma; malignant glioma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Biomarker of lung cancer (multiple); malignant glioma (multiple); medulloblastoma; and non-functioning pancreatic endocrine tumor.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cell division protein kinase 6; cyclin-dependent kinase 6; MCPH12; MGC59692; PLSTIRE; serine/threonine-protein kinase PLSTIRE
Orthologs:
Mus musculus (house mouse) : Cdk6 (cyclin-dependent kinase 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdk6 (cyclin-dependent kinase 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk6 (cyclin dependent kinase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK6 (cyclin dependent kinase 6)
Canis lupus familiaris (dog) : CDK6 (cyclin dependent kinase 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk6 (cyclin dependent kinase 6)
Sus scrofa (pig) : CDK6 (cyclin dependent kinase 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38792,604,921 - 92,836,627 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37792,234,235 - 92,465,941 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36792,072,171 - 92,301,148 (-)NCBINCBI36hg18NCBI36
Build 34791,878,887 - 92,107,863NCBI
Celera786,938,762 - 87,170,471 (-)NCBI
Cytogenetic Map7q21.2NCBI
HuRef786,843,599 - 87,075,188 (-)NCBIHuRef
CHM1_1792,164,273 - 92,395,977 (-)NCBICHM1_1
CRA_TCAGchr7v2791,563,451 - 91,795,159 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CDK6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735400
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.