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Gene: HRH4 (histamine receptor H4) Homo sapiens
Symbol: HRH4
Name: histamine receptor H4
Description: Predicted to have G protein-coupled acetylcholine receptor activity and G protein-coupled serotonin receptor activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; chemical synaptic transmission; and inflammatory response. Predicted to localize to the dendrite and integral component of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AXOR35; BG26; G-protein coupled receptor 105; GPCR105; GPRv53; H4; H4R; HH4R; histamine H4 receptor; MGC133027; pfi-013; SP9144
Mus musculus (house mouse) : Hrh4 (histamine receptor H4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hrh4 (histamine receptor H4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hrh4 (histamine receptor H4)
Pan paniscus (bonobo/pygmy chimpanzee) : HRH4 (histamine receptor H4)
Canis lupus familiaris (dog) : HRH4 (histamine receptor H4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hrh4 (histamine receptor H4)
Sus scrofa (pig) : HRH4 (histamine receptor H4)
Chlorocebus sabaeus (African green monkey) : HRH4 (histamine receptor H4)
Heterocephalus glaber (naked mole-rat) : Hrh4 (histamine receptor H4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1824,460,637 - 24,479,961 (+)EnsemblGRCh38hg38GRCh38
GRCh381824,460,637 - 24,479,974 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371822,040,593 - 22,059,921 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361820,294,591 - 20,313,919 (+)NCBINCBI36hg18NCBI36
Build 341820,294,590 - 20,313,918NCBI
Celera1818,855,629 - 18,874,954 (+)NCBI
Cytogenetic Map18q11.2NCBI
HuRef1818,896,649 - 18,915,969 (+)NCBIHuRef
CHM1_11821,967,599 - 21,986,980 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HRH4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735405
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.