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Gene: IL1R1 (interleukin 1 receptor type 1) Homo sapiens
Symbol: IL1R1
Name: interleukin 1 receptor type 1
Description: Exhibits interleukin-1 receptor activity and platelet-derived growth factor receptor binding activity. Involved in interleukin-1-mediated signaling pathway; positive regulation of T-helper 1 cell cytokine production; and positive regulation of interferon-gamma production. Localizes to the membrane. Implicated in systemic scleroderma and type 1 diabetes mellitus. Biomarker of cholesteatoma of middle ear.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antigen CD121a; CD121 antigen-like family member A; CD121A; D2S1473; IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1; IL1R; IL1RA; interleukin 1 receptor alpha, type I; interleukin 1 receptor, type I; interleukin receptor 1; interleukin-1 receptor alpha; interleukin-1 receptor type 1; interleukin-1 receptor type I; P80
Mus musculus (house mouse) : Il1r1 (interleukin 1 receptor, type I)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il1r1 (interleukin 1 receptor type 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il1r1 (interleukin 1 receptor type 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IL1R1 (interleukin 1 receptor type 1)
Canis lupus familiaris (dog) : IL1R1 (interleukin 1 receptor type 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il1r1 (interleukin 1 receptor type 1)
Sus scrofa (pig) : IL1R1 (interleukin 1 receptor type 1)
Chlorocebus sabaeus (African green monkey) : IL1R1 (interleukin 1 receptor type 1)
Heterocephalus glaber (naked mole-rat) : Il1r1 (interleukin 1 receptor type 1)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   OSTEAR10_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2102,064,544 - 102,179,874 (+)Ensembl
GRCh382102,069,638 - 102,179,874 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372102,686,836 - 102,796,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,136,834 - 102,162,766 (+)NCBINCBI36hg18NCBI36
Build 342102,228,919 - 102,254,852NCBI
Celera296,971,617 - 96,997,550 (+)NCBI
Cytogenetic Map2q11.2-q12.1NCBI
HuRef296,534,264 - 96,560,197 (+)NCBIHuRef
CHM1_12102,691,224 - 102,800,675 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IL1R1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735430
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.