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Gene: NFKBIA (NFKB inhibitor alpha) Homo sapiens
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Symbol: NFKBIA
Name: NFKB inhibitor alpha
CRRD ID: 735440
Description: Exhibits several functions, including NF-kappaB binding activity; nuclear localization sequence binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of macrophage derived foam cell differentiation; positive regulation of cholesterol efflux; and regulation of transcription, DNA-templated. Localizes to cytosol; nucleus; and plasma membrane. Implicated in hematologic cancer (multiple); hypohidrotic ectodermal dysplasia; lung cancer; melanoma; and prostate cancer. Biomarker of prostate adenocarcinoma and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EDAID2; I-kappa-B-alpha; IkappaBalpha; ikB-alpha; IKBA; MAD-3; major histocompatibility complex enhancer-binding protein MAD3; NF-kappa-B inhibitor alpha; NFKBI; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light chain gene enhancer in b-cells inhibitor, alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Orthologs:
Mus musculus (house mouse) : Nfkbia (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nfkbia (NFKB inhibitor alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfkbia (NFKB inhibitor alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : NFKBIA (NFKB inhibitor alpha)
Canis lupus familiaris (dog) : NFKBIA (NFKB inhibitor alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfkbia (NFKB inhibitor alpha)
Sus scrofa (pig) : NFKBIA (NFKB inhibitor alpha)
Chlorocebus sabaeus (African green monkey) : NFKBIA (NFKB inhibitor alpha)
Heterocephalus glaber (naked mole-rat) : Nfkbia (NFKB inhibitor alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1435,401,511 - 35,404,749 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1435,401,513 - 35,404,749 (-)EnsemblGRCh38hg38GRCh38
GRCh381435,401,513 - 35,404,749 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371435,870,716 - 35,873,960 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361434,940,468 - 34,943,695 (-)NCBINCBI36hg18NCBI36
Build 341434,940,467 - 34,943,695NCBI
Celera1415,734,587 - 15,737,850 (-)NCBI
Cytogenetic Map14q13.2NCBI
HuRef1415,984,422 - 15,987,685 (-)NCBIHuRef
CHM1_11435,870,469 - 35,873,713 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations