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Gene: CTSH (cathepsin H) Homo sapiens
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Symbol: CTSH
Name: cathepsin H
Description: Exhibits several functions, including HLA-A specific activating MHC class I receptor activity; cysteine-type endopeptidase activator activity involved in apoptotic process; and peptidase activity, acting on L-amino acid peptides. Involved in several processes, including peptide catabolic process; positive regulation of macromolecule metabolic process; and proteolysis. Localizes to several cellular components, including alveolar lamellar body; cytoplasmic ribonucleoprotein granule; and lysosome. Biomarker of Huntington's disease; glioblastoma multiforme; and transitional cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACC-4; ACC-5; ACC4; ACC5; aleurain; cathepsin B3; cathepsin BA; CPSB; DKFZp686B24257; MGC1519; minichain; N-benzoylarginine-beta-naphthylamide hydrolase; pro-cathepsin H
Orthologs:
Mus musculus (house mouse) : Ctsh (cathepsin H)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ctsh (cathepsin H)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ctsh (cathepsin H)
Pan paniscus (bonobo/pygmy chimpanzee) : CTSH (cathepsin H)
Canis lupus familiaris (dog) : CTSH (cathepsin H)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ctsh (cathepsin H)
Sus scrofa (pig) : CTSH (cathepsin H)
Chlorocebus sabaeus (African green monkey) : CTSH (cathepsin H)
Heterocephalus glaber (naked mole-rat) : Ctsh (cathepsin H)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1578,921,058 - 78,949,574 (-)EnsemblGRCh38hg38GRCh38
GRCh381578,921,058 - 78,945,098 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371579,214,092 - 79,237,436 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361577,001,147 - 77,024,475 (-)NCBINCBI36hg18NCBI36
Build 341577,001,162 - 77,024,475NCBI
Celera1556,150,437 - 56,173,763 (-)NCBI
Cytogenetic Map15q25.1NCBI
HuRef1555,974,005 - 55,997,318 (-)NCBIHuRef
CHM1_11579,332,284 - 79,355,647 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CTSH
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735454
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.