Gene: THBS4 (thrombospondin 4) Homo sapiens
Symbol: THBS4
Name: thrombospondin 4
Description: The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: thrombospondin-4; TSP-4; TSP4
Mus musculus (house mouse) : Thbs4 (thrombospondin 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Thbs4 (thrombospondin 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Thbs4 (thrombospondin 4)
Pan paniscus (bonobo/pygmy chimpanzee) : THBS4 (thrombospondin 4)
Canis lupus familiaris (dog) : THBS4 (thrombospondin 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Thbs4 (thrombospondin 4)
Sus scrofa (pig) : THBS4 (thrombospondin 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38579,991,296 - 80,083,753 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37579,331,170 - 79,379,111 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36579,366,747 - 79,414,866 (+)NCBINCBI36hg18NCBI36
Build 34579,366,746 - 79,414,861NCBI
Celera575,232,509 - 75,280,442 (+)NCBI
Cytogenetic Map5q14.1NCBI
HuRef574,539,053 - 74,586,983 (+)NCBIHuRef
CHM1_1578,720,207 - 78,812,159 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on THBS4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735475
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-05-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.