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Gene: Mre11a (MRE11A homolog A, double strand break repair nuclease) Mus musculus
Symbol: Mre11a
Name: MRE11A homolog A, double strand break repair nuclease
Description: Predicted to contribute to DNA binding activity and DNA helicase activity. Involved in several processes, including double-strand break repair; mitotic DNA damage checkpoint; and synapsis. Localizes to the PML body. Colocalizes with the nuclear chromosome, telomeric region. Human ortholog(s) of this gene implicated in breast carcinoma; endometrial cancer; stomach carcinoma; and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease); PARTICIPATES IN altered p53 signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: double-strand break repair protein MRE11; double-strand break repair protein MRE11A; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; mmMRE11A; Mre11; MRE11 homolog 1; MRE11 homolog A; Mre11b
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl914,784,654 - 14,837,123 (+)Ensembl
GRCm38914,784,654 - 14,837,125 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37914,589,151 - 14,638,861 (+)NCBIGRCm37mm9NCBIm37
MGSCv36914,535,100 - 14,584,812 (+)NCBImm8
Celera912,065,444 - 12,115,180 (+)NCBICelera
Cytogenetic Map9 A2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Mre11a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735478
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.