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Gene: AMBP (alpha-1-microglobulin/bikunin precursor) Homo sapiens
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Symbol: AMBP
Name: alpha-1-microglobulin/bikunin precursor
CRRD ID: 735479
Description: Exhibits IgA binding activity; heme binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of JNK cascade and receptor-mediated endocytosis. Localizes to plasma membrane. Implicated in acute kidney failure and adult respiratory distress syndrome. Biomarker of asthma; calcium oxalate nephrolithiasis; kidney failure; and pyelonephritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A1M; alpha 1 microglobulin/bikunin; alpha-1-microglobulin/bikunin; bikunin; complex-forming glycoprotein heterogeneous in charge; EDC1; growth-inhibiting protein 19; HCP; HI30; IATIL; inter-alpha-trypsin inhibitor light chain; ITI; ITIL; ITILC; protein HC; trypstatin; uristatin; uronic-acid-rich protein; UTI
Orthologs:
Mus musculus (house mouse) : Ambp (alpha 1 microglobulin/bikunin precursor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ambp (alpha-1-microglobulin/bikunin precursor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ambp (alpha-1-microglobulin/bikunin precursor)
Pan paniscus (bonobo/pygmy chimpanzee) : AMBP (alpha-1-microglobulin/bikunin precursor)
Canis lupus familiaris (dog) : AMBP (alpha-1-microglobulin/bikunin precursor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ambp (alpha-1-microglobulin/bikunin precursor)
Sus scrofa (pig) : AMBP (alpha-1-microglobulin/bikunin precursor)
Chlorocebus sabaeus (African green monkey) : AMBP (alpha-1-microglobulin/bikunin precursor)
Heterocephalus glaber (naked mole-rat) : Ambp (alpha-1-microglobulin/bikunin precursor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9114,060,127 - 114,078,328 (-)EnsemblGRCh38hg38GRCh38
GRCh389114,060,127 - 114,078,300 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379116,822,407 - 116,840,752 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369115,862,228 - 115,880,536 (-)NCBINCBI36hg18NCBI36
Build 349113,901,963 - 113,920,269NCBI
Celera987,469,703 - 87,488,044 (-)NCBI
Cytogenetic Map9q32NCBI
HuRef986,428,731 - 86,447,071 (-)NCBIHuRef
CHM1_19116,968,857 - 116,987,201 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on AMBP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735479
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.