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Gene: NEDD8 (NEDD8 ubiquitin like modifier) Homo sapiens
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Symbol: NEDD8
Name: NEDD8 ubiquitin like modifier
Description: Exhibits ubiquitin protein ligase binding activity. Involved in protein neddylation. Localizes to the cytosol and nucleoplasm. Biomarker of Parkinson's disease and astrocytoma; PARTICIPATES IN p53 signaling pathway; neddylation pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; aflatoxin B1; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ43224; MGC104393; MGC125896; MGC125897; Nedd-8; neddylin; neural precursor cell expressed developmentally down-regulated protein 8; neural precursor cell expressed, developmentally down-regulated 8; neural precursor cell expressed, developmentally down-regulated gene 8; ubiquitin-like protein Nedd8
Orthologs:
Mus musculus (house mouse) : Nedd8 (neural precursor cell expressed, developmentally down-regulated gene 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nedd8 (NEDD8 ubiquitin like modifier)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nedd8 (NEDD8 ubiquitin like modifier)
Pan paniscus (bonobo/pygmy chimpanzee) : NEDD8 (NEDD8 ubiquitin like modifier)
Canis lupus familiaris (dog) : NEDD8 (NEDD8 ubiquitin like modifier)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nedd8 (NEDD8 ubiquitin like modifier)
Sus scrofa (pig) : NEDD8 (NEDD8 ubiquitin like modifier)
more info ...
Related Pseudogenes: NEDD8P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,216,857 - 24,232,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371424,686,057 - 24,701,576 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,755,897 - 23,771,416 (-)NCBINCBI36hg18NCBI36
Build 341423,755,911 - 23,771,412NCBI
Celera144,550,695 - 4,566,214 (-)NCBI
Cytogenetic Map14q12NCBI
HuRef144,801,062 - 4,816,345 (-)NCBIHuRef
CHM1_11424,684,707 - 24,700,199 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NEDD8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735521
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.