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Gene: NEDD8 (NEDD8 ubiquitin like modifier) Homo sapiens
Symbol: NEDD8
Name: NEDD8 ubiquitin like modifier
Description: Exhibits ubiquitin protein ligase binding activity. Involved in protein neddylation. Localizes to the cytosol and nucleoplasm. Biomarker of Parkinson's disease and astrocytoma; PARTICIPATES IN p53 signaling pathway; neddylation pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; aflatoxin B1; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ43224; MGC104393; MGC125896; MGC125897; Nedd-8; neddylin; neural precursor cell expressed developmentally down-regulated protein 8; neural precursor cell expressed, developmentally down-regulated 8; neural precursor cell expressed, developmentally down-regulated gene 8; ubiquitin-like protein Nedd8
Mus musculus (house mouse) : Nedd8 (neural precursor cell expressed, developmentally down-regulated gene 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nedd8 (NEDD8 ubiquitin like modifier)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nedd8 (NEDD8 ubiquitin like modifier)
Pan paniscus (bonobo/pygmy chimpanzee) : NEDD8 (NEDD8 ubiquitin like modifier)
Canis lupus familiaris (dog) : NEDD8 (NEDD8 ubiquitin like modifier)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nedd8 (NEDD8 ubiquitin like modifier)
Sus scrofa (pig) : NEDD8 (NEDD8 ubiquitin like modifier)
more info ...
Related Pseudogenes: NEDD8P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381424,216,857 - 24,232,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371424,686,057 - 24,701,576 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,755,897 - 23,771,416 (-)NCBINCBI36hg18NCBI36
Build 341423,755,911 - 23,771,412NCBI
Celera144,550,695 - 4,566,214 (-)NCBI
Cytogenetic Map14q12NCBI
HuRef144,801,062 - 4,816,345 (-)NCBIHuRef
CHM1_11424,684,707 - 24,700,199 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NEDD8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735521
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.