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Gene: MBL2 (mannose binding lectin 2) Homo sapiens
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Symbol: MBL2
Name: mannose binding lectin 2
Description: Exhibits calcium-dependent protein binding activity; mannose binding activity; and signaling receptor binding activity. Involved in complement activation, lectin pathway; defense response to Gram-positive bacterium; and negative regulation of viral process. Localizes to the extracellular space. Implicated in several diseases, including autoimmune hypersensitivity disease (multiple); fungal infectious disease (multiple); liver disease (multiple); lung disease (multiple); and vasculitis (multiple). Biomarker of several diseases, including Behcet's disease; Legionnaires' disease; coccidioidomycosis; liver disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: COLEC1; collectin-1; HSMBPC; mannan-binding lectin; mannose-binding lectin (protein C) 2, soluble (opsonic defect); mannose-binding lectin 2, soluble (opsonic defect); mannose-binding protein C; mannose-binding protein c (liver); MBL; MBL2D; MBP; MBP-C; MBP1; MBPD; MGC116832; MGC116833
Orthologs:
Mus musculus (house mouse) : Mbl2 (mannose-binding lectin (protein C) 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mbl2 (mannose binding lectin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mbl2 (mannose binding lectin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MBL2 (mannose binding lectin 2)
Canis lupus familiaris (dog) : MBL2 (mannose binding lectin 2)
Sus scrofa (pig) : MBL2 (mannose binding lectin 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: MBP (Gene ID: 4155) and MBL2 (Gene ID: 4153) share the MBP symbol/alias in common. MBP is a widely used alternative name for mannose binding lectin 2 (MBL2), which can be confused with the official symbol for MBP (myelin basic protein, GeneID 4155). [01 Jun 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381052,764,977 - 52,772,847 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371054,525,140 - 54,532,578 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361054,195,146 - 54,201,466 (-)NCBINCBI36hg18NCBI36
Build 341054,195,146 - 54,201,466NCBI
Celera1047,788,072 - 47,794,392 (-)NCBI
Cytogenetic Map10q21.1NCBI
HuRef1048,503,748 - 48,510,068 (-)NCBIHuRef
CHM1_11054,806,939 - 54,813,257 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MBL2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735547
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.