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Gene: AIF1 (allograft inflammatory factor 1) Homo sapiens
Symbol: AIF1
Name: allograft inflammatory factor 1
CRRD ID: 735562
Description: Exhibits actin filament binding activity. Involved in several processes, including positive regulation of cytokine production; regulation of cell migration; and regulation of smooth muscle cell proliferation. Localizes to cytosol; nucleus; and perinuclear region of cytoplasm. Colocalizes with actin filament and ruffle membrane. Implicated in type 1 diabetes mellitus. Biomarker of Alzheimer's disease and brain infarction.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AIF-1; allograft inflammatory factor-1 splice variant Hara-1; IBA1; interferon gamma responsive transcript; ionized calcium-binding adapter molecule 1; IRT-1; IRT1; protein G1
Mus musculus (house mouse) : Aif1 (allograft inflammatory factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Aif1 (allograft inflammatory factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aif1 (allograft inflammatory factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AIF1 (allograft inflammatory factor 1)
Canis lupus familiaris (dog) : AIF1 (allograft inflammatory factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aif1 (allograft inflammatory factor 1)
Sus scrofa (pig) : AIF1 (allograft inflammatory factor 1)
Heterocephalus glaber (naked mole-rat) : Aif1 (allograft inflammatory factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl631,615,217 - 31,617,021 (+)EnsemblGRCh38hg38GRCh38
GRCh38631,615,212 - 31,617,015 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,582,969 - 31,584,798 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,691,012 - 31,692,777 (+)NCBINCBI36hg18NCBI36
Build 34631,691,767 - 31,692,777NCBI
Celera633,181,222 - 33,183,026 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,369,335 - 31,370,975 (+)NCBIHuRef
CHM1_1631,585,122 - 31,586,938 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on AIF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735562
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.