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Gene: Plcb1 (phospholipase C, beta 1) Mus musculus
Symbol: Plcb1
Name: phospholipase C, beta 1
Description: Exhibits lamin binding activity and phosphatidylinositol phospholipase C activity. Involved in several processes, including positive regulation of cell cycle process; regulation of cellular macromolecule biosynthetic process; and regulation of trans-synaptic signaling. Localizes to several cellular components, including the GABA-ergic synapse; glutamatergic synapse; and nuclear lumen. Used to study Alzheimer's disease and schizophrenia. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 12 and myelodysplastic syndrome. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human PLCB1 (phospholipase C beta 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; 3110043I21Rik; AI132408; mKIAA0581; phosphoinositide phospholipase C; phosphoinositide phospholipase C-beta-1; phospholipase C-beta-1; phospholipase C-beta-1a; PLC-154; PLC-beta-1; Plcb
Homo sapiens (human) : PLCB1 (phospholipase C beta 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Plcb1 (phospholipase C beta 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plcb1 (phospholipase C beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PLCB1 (phospholipase C beta 1)
Canis lupus familiaris (dog) : PLCB1 (phospholipase C beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plcb1 (phospholipase C beta 1)
Sus scrofa (pig) : PLCB1 (phospholipase C beta 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382134,786,164 - 135,475,258 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372134,611,900 - 135,300,994 (+)NCBIGRCm37mm9NCBIm37
MGSCv362134,477,971 - 135,163,863 (+)NCBImm8
Celera2135,990,426 - 136,678,579 (+)NCBICelera
Cytogenetic Map2 F3NCBI
cM Map265.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Plcb1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735582
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.