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Gene: PPP2CA (protein phosphatase 2 catalytic subunit alpha) Homo sapiens
Symbol: PPP2CA
Name: protein phosphatase 2 catalytic subunit alpha
Description: Exhibits protein heterodimerization activity and protein serine/threonine phosphatase activity. Involved in negative regulation of epithelial to mesenchymal transition; peptidyl-threonine dephosphorylation; and positive regulation of protein serine/threonine kinase activity. Localizes to the membrane raft and protein phosphatase type 2A complex. Biomarker of Parkinson's disease; congestive heart failure; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: NEDLBA; PP2A-alpha; PP2Ac; PP2CA; PP2Calpha; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2A catalytic subunit, alpha isoform; protein phosphatase 2a, catalytic subunit, alpha isoform; replication protein C; RP-C; serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385134,194,332 - 134,226,073 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375133,532,148 - 133,561,950 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,560,047 - 133,589,849 (-)NCBINCBI36hg18NCBI36
Build 345133,560,046 - 133,589,849NCBI
Celera5129,655,849 - 129,685,663 (-)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5128,717,117 - 128,746,747 (-)NCBIHuRef
CHM1_15132,964,711 - 132,994,524 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PPP2CA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735585
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.