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Gene: LDLR (low density lipoprotein receptor) Homo sapiens
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Symbol: LDLR
Name: low density lipoprotein receptor
Description: Exhibits several functions, including identical protein binding activity; lipoprotein particle receptor activity; and low-density lipoprotein particle binding activity. Involved in several processes, including cholesterol homeostasis; cholesterol transport; and long-term memory. Localizes to several cellular components, including PCSK9-LDLR complex; clathrin-coated pit; and endosome. Implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Biomarker of systemic lupus erythematosus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FH; FHC; FHCL1; LDL receptor; LDLCQ2; low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
Orthologs:
Mus musculus (house mouse) : Ldlr (low density lipoprotein receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ldlr (low density lipoprotein receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ldlr (low density lipoprotein receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : LDLR (low density lipoprotein receptor)
Canis lupus familiaris (dog) : LDLR (low density lipoprotein receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ldlr (low density lipoprotein receptor)
Sus scrofa (pig) : LDLR (low density lipoprotein receptor)
Chlorocebus sabaeus (African green monkey) : LDLR (low density lipoprotein receptor)
Heterocephalus glaber (naked mole-rat) : Ldlr (low density lipoprotein receptor)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   BP50_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1911,089,462 - 11,133,820 (+)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl1911,089,362 - 11,133,816 (+)EnsemblGRCh38hg38GRCh38
GRCh381911,089,432 - 11,133,820 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371911,200,037 - 11,244,506 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,061,132 - 11,105,490 (+)NCBINCBI36hg18NCBI36
Build 341911,061,131 - 11,105,490NCBI
Celera1911,094,887 - 11,139,322 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,777,128 - 10,820,847 (+)NCBIHuRef
CHM1_11911,201,264 - 11,245,760 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model