Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: FH (fumarate hydratase) Homo sapiens
Analyze
Symbol: FH
Name: fumarate hydratase
Description: Exhibits fumarate hydratase activity and histone binding activity. Involved in several processes, including dicarboxylic acid metabolic process; negative regulation of histone H3-K36 methylation; and positive regulation of double-strand break repair via nonhomologous end joining. Localizes to several cellular components, including cytosol; mitochondrion; and site of double-strand break. Implicated in fumarase deficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FMRD; fumarase; fumarate hydratase 1; fumarate hydratase, mitochondrial; HLRCC; HsFH; LRCC; MCL; MCUL1
Orthologs:
Mus musculus (house mouse) : Fh1 (fumarate hydratase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fh (fumarate hydratase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fh (fumarate hydratase)
Pan paniscus (bonobo/pygmy chimpanzee) : FH (fumarate hydratase)
Canis lupus familiaris (dog) : FH (fumarate hydratase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fh (fumarate hydratase)
Sus scrofa (pig) : FH (fumarate hydratase)
Chlorocebus sabaeus (African green monkey) : FH (fumarate hydratase)
Heterocephalus glaber (naked mole-rat) : Fh (fumarate hydratase)
more info ...
Related Pseudogenes: FHP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1241,497,603 - 241,519,761 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1241,497,603 - 241,519,755 (-)EnsemblGRCh38hg38GRCh38
GRCh381241,497,603 - 241,519,755 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371241,660,857 - 241,683,085 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361239,727,526 - 239,749,677 (-)NCBINCBI36hg18NCBI36
Build 341237,986,946 - 238,009,095NCBI
Celera1214,915,854 - 214,938,092 (-)NCBI
Cytogenetic Map1q43NCBI
HuRef1212,119,119 - 212,141,338 (-)NCBIHuRef
CHM1_11242,933,564 - 242,955,781 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants