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Gene: CD4 (CD4 molecule) Homo sapiens
Symbol: CD4
Name: CD4 molecule
Description: Exhibits several functions, including interleukin-16 binding activity; interleukin-16 receptor activity; and protein homodimerization activity. Involved in several processes, including cellular response to cytokine stimulus; leukocyte differentiation; and positive regulation of protein phosphorylation. Localizes to the external side of plasma membrane; integral component of plasma membrane; and membrane raft.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cd4 antigen; CD4 antigen (p55); CD4 receptor; CD4mut; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4
Mus musculus (house mouse) : Cd4 (CD4 antigen)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd4 (Cd4 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd4 (CD4 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD4 (CD4 molecule)
Canis lupus familiaris (dog) : CD4 (CD4 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd4 (CD4 molecule)
Sus scrofa (pig) : CD4 (CD4 molecule)
Chlorocebus sabaeus (African green monkey) : CD4 (CD4 molecule)
Heterocephalus glaber (naked mole-rat) : Cd4 (CD4 molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl126,786,858 - 6,820,799 (+)Ensembl
GRCh38126,789,528 - 6,820,810 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37126,898,638 - 6,929,976 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,768,912 - 6,800,237 (+)NCBINCBI36hg18NCBI36
Build 34126,769,004 - 6,800,235NCBI
Celera128,515,970 - 8,547,252 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef126,751,975 - 6,783,457 (+)NCBIHuRef
CHM1_1126,897,616 - 6,928,653 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CD4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735603
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.