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Gene: AKT3 (AKT serine/threonine kinase 3) Homo sapiens
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Symbol: AKT3
Name: AKT serine/threonine kinase 3
Description: Exhibits ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of cellular senescence; positive regulation of cell migration involved in sprouting angiogenesis; and positive regulation of vascular endothelial cell proliferation. Predicted to localize to cytoplasm; membrane; and nucleus. Implicated in colon cancer; glioblastoma multiforme; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Biomarker of astrocytoma; lung non-small cell carcinoma; and pancreatic adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp434N0250; MPPH; MPPH2; PKB gamma; PKB-GAMMA; PKBG; PRKBG; protein kinase Akt-3; protein kinase B gamma; RAC-gamma; RAC-gamma serine/threonine protein kinase; RAC-gamma serine/threonine-protein kinase; RAC-PK-gamma; serine threonine protein kinase, Akt-3; STK-2; thymoma viral proto-oncogene 3; v-akt murine thymoma viral oncogene homolog 3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Orthologs:
Mus musculus (house mouse) : Akt3 (thymoma viral proto-oncogene 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Akt3 (AKT serine/threonine kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Akt3 (AKT serine/threonine kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : AKT3 (AKT serine/threonine kinase 3)
Canis lupus familiaris (dog) : AKT3 (AKT serine/threonine kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akt3 (AKT serine/threonine kinase 3)
Sus scrofa (pig) : AKT3 (AKT serine/threonine kinase 3)
Chlorocebus sabaeus (African green monkey) : AKT3 (AKT serine/threonine kinase 3)
Heterocephalus glaber (naked mole-rat) : Akt3 (AKT serine/threonine kinase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1243,488,233 - 243,851,079 (-)EnsemblGRCh38hg38GRCh38
GRCh381243,488,233 - 243,851,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371243,651,535 - 244,014,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361241,718,158 - 242,073,176 (-)NCBINCBI36hg18NCBI36
Build 341239,977,575 - 240,332,594NCBI
Celera1216,939,341 - 217,293,898 (-)NCBI
Cytogenetic Map1q43-q44NCBI
HuRef1214,031,579 - 214,386,139 (-)NCBIHuRef
CHM1_11244,924,165 - 245,279,192 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AKT3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735623
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.