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Gene: ASCL2 (achaete-scute family bHLH transcription factor 2) Homo sapiens
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Symbol: ASCL2
Name: achaete-scute family bHLH transcription factor 2
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific and E-box binding activity. Predicted to contribute to DNA-binding transcription factor activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; response to hypoxia; and spongiotrophoblast layer development. Localizes to cytoplasm and nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: achaete-scute complex homolog 2; achaete-scute complex homolog-like 2 (drosophila); achaete-scute complex-like 2; achaete-scute homolog 2; ASH-2; ASH2; bHLHa45; class A basic helix-loop-helix protein 45; HASH2; mammalian achaete/scute homologue 2; MASH2
Orthologs:
Mus musculus (house mouse) : Ascl2 (achaete-scute family bHLH transcription factor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ascl2 (achaete-scute family bHLH transcription factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ascl2 (achaete-scute family bHLH transcription factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ASCL2 (achaete-scute family bHLH transcription factor 2)
Canis lupus familiaris (dog) : ASCL2 (achaete-scute family bHLH transcription factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ascl2 (achaete-scute family bHLH transcription factor 2)
Sus scrofa (pig) : ASCL2 (achaete-scute family bHLH transcription factor 2)
Chlorocebus sabaeus (African green monkey) : ASCL2 (achaete-scute family bHLH transcription factor 2)
Heterocephalus glaber (naked mole-rat) : Ascl2 (achaete-scute family bHLH transcription factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl112,268,495 - 2,270,952 (-)EnsemblGRCh38hg38GRCh38
GRCh38112,268,498 - 2,270,952 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,289,728 - 2,292,182 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,246,304 - 2,248,758 (-)NCBINCBI36hg18NCBI36
Build 34112,246,304 - 2,248,758NCBI
Celera112,325,551 - 2,328,006 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef112,079,884 - 2,082,454 (-)NCBIHuRef
CHM1_1112,288,463 - 2,290,917 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ASCL2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735625
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.