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Gene: Cyp11a1 (cytochrome P450, family 11, subfamily a, polypeptide 1) Mus musculus
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
CRRD ID: 735632
Description: Exhibits cholesterol monooxygenase (side-chain-cleaving) activity. Involved in C21-steroid hormone biosynthetic process. Localizes to mitochondrion. Is expressed in several structures, including endocrine gland; lung; reproductive system; spleen; and urinary system. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH (S)-nicotine; 1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cholesterol desmolase; cholesterol side chain cleavage; cholesterol side-chain cleavage enzyme, mitochondrial; csc; cscc; Cyp1; Cyp11a; Cypxia1; cytochrome P450 11A1; cytochrome P450 side-chain cleavage enzyme; cytochrome P450(scc); cytochrome P450, 11a, cholesterol side-chain cleavage; D9Ertd411; D9Ertd411e; P450s; P450scc; Sc; Scc
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl958,006,411 - 58,027,023 (+)EnsemblGRCm38mm10GRCm38
GRCm38957,998,024 - 58,027,031 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37957,862,824 - 57,874,830 (+)NCBIGRCm37mm9NCBIm37
MGSCv36957,813,153 - 57,825,158 (+)NCBImm8
Celera955,247,551 - 55,259,829 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cyp11a1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735632
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.