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Gene: AR (androgen receptor) Homo sapiens
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Symbol: AR
Name: androgen receptor
Description: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AIS; androgen nuclear receptor variant 2; androgen receptor splice variant 4b; AR8; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; Kennedy disease; NR3C4; nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; spinal and bulbar muscular atrophy; testicular feminization; TFM
Orthologs:
Mus musculus (house mouse) : Ar (androgen receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ar (androgen receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ar (androgen receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : AR (androgen receptor)
Canis lupus familiaris (dog) : AR (androgen receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ar (androgen receptor)
Sus scrofa (pig) : AR (androgen receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X67,544,623 - 67,730,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X66,763,874 - 66,950,461 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X66,680,599 - 66,860,844 (+)NCBINCBI36hg18NCBI36
Build 34X66,571,703 - 66,727,140NCBI
CeleraX67,112,960 - 67,293,967 (+)NCBI
Cytogenetic MapXq12NCBI
HuRefX60,592,006 - 60,778,929 (+)NCBIHuRef
CHM1_1X66,656,369 - 66,842,989 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations