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Gene: IL1A (interleukin 1 alpha) Homo sapiens
Symbol: IL1A
Name: interleukin 1 alpha
Description: Exhibits copper ion binding activity and cytokine activity. Involved in several processes, including cellular response to heat; positive regulation of cytokine production; and response to copper ion. Localizes to cytosol and extracellular space. Implicated in several diseases, including Fabry disease; Schnitzler syndrome; hematologic cancer (multiple); lung disease (multiple); and rheumatoid arthritis (multiple). Biomarker of several diseases, including arthritis (multiple); beta thalassemia; cholesteatoma (multiple); common cold; and glucose metabolism disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hematopoietin-1; IL-1 alpha; IL-1A; IL1; IL1-ALPHA; IL1F1; interleukin 1, alpha; interleukin-1 alpha; preinterleukin 1 alpha; pro-interleukin-1-alpha
Mus musculus (house mouse) : Il1a (interleukin 1 alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il1a (interleukin 1 alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il1a (interleukin 1 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : IL1A (interleukin 1 alpha)
Canis lupus familiaris (dog) : IL1A (interleukin 1 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il1a (interleukin 1 alpha)
Sus scrofa (pig) : IL1A (interleukin 1 alpha)
Chlorocebus sabaeus (African green monkey) : IL1A (interleukin 1 alpha)
Heterocephalus glaber (naked mole-rat) : Il1a (interleukin 1 alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2112,773,925 - 112,784,493 (-)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl2112,773,915 - 112,784,590 (-)EnsemblGRCh38hg38GRCh38
GRCh382112,773,925 - 112,784,493 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372113,531,492 - 113,542,971 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,247,963 - 113,259,442 (-)NCBINCBI36hg18NCBI36
Build 342113,247,723 - 113,259,202NCBI
Celera2106,917,026 - 106,928,133 (-)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2105,986,068 - 105,997,547 (-)NCBIHuRef
CHM1_12113,535,646 - 113,546,810 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IL1A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735707
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-04-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.