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Gene: CYP1A2 (cytochrome P450 family 1 subfamily A member 2) Homo sapiens
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Symbol: CYP1A2
Name: cytochrome P450 family 1 subfamily A member 2
Description: Exhibits several functions, including caffeine oxidase activity; heme binding activity; and steroid hydroxylase activity. Involved in several processes, including cellular hormone metabolic process; exogenous drug catabolic process; and oxidative deethylation. Localizes to intracellular membrane-bounded organelle. Implicated in breast cancer; chronic obstructive pulmonary disease; endometrial cancer; and porphyria cutanea tarda.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: aryl hydrocarbon hydroxylase; cholesterol 25-hydroxylase; CP12; CYPIA2; cytochrome P(3)450; cytochrome P450 1A2; cytochrome P450 4; cytochrome p450, 1a2; cytochrome P450, family 1, subfamily A, polypeptide 2; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; cytochrome P450-P3; dioxin-inducible P3-450; flavoprotein-linked monooxygenase; hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P3-450; P450 form 4; P450(PA); xenobiotic monooxygenase
Orthologs:
Mus musculus (house mouse) : Cyp1a2 (cytochrome P450, family 1, subfamily a, polypeptide 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cyp1a2 (cytochrome P450, family 1, subfamily a, polypeptide 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102010322 (cytochrome P450 1A2)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP1A2 (cytochrome P450 family 1 subfamily A member 2)
Canis lupus familiaris (dog) : CYP1A2 (cytochrome P450 family 1 subfamily A member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101969421 (cytochrome P450 1A2)
Sus scrofa (pig) : CYP1A2 (cytochrome P450, family 1, subfamily A, polypeptide 2)
Chlorocebus sabaeus (African green monkey) : CYP1A2 (cytochrome P450 family 1 subfamily A member 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1574,748,845 - 74,756,607 (+)EnsemblGRCh38hg38GRCh38
GRCh381574,748,845 - 74,756,607 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371575,041,184 - 75,048,941 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,828,237 - 72,835,994 (+)NCBINCBI36hg18NCBI36
Build 341572,828,236 - 72,835,994NCBI
Celera1551,991,217 - 51,998,975 (+)NCBI
Cytogenetic Map15q24.1NCBI
HuRef1551,838,984 - 51,846,743 (+)NCBIHuRef
CHM1_11575,159,686 - 75,167,443 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations