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Gene: PLAU (plasminogen activator, urokinase) Homo sapiens
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Symbol: PLAU
Name: plasminogen activator, urokinase
Description: Predicted to have serine-type endopeptidase activity. Involved in several processes, including plasminogen activation; regulation of cell migration; and regulation of smooth muscle cell-matrix adhesion. Localizes to the cell surface and extracellular space. Implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal failure; lung disease (multiple); and mitral valve prolapse. Biomarker of several diseases, including appendicitis; carcinoma (multiple); chronic obstructive pulmonary disease; end stage renal failure; and hepatitis B.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATF; BDPLT5; plasminogen activator, urinary; QPD; u-PA; U-plasminogen activator; UPA; URK; urokinase-type plasminogen activator
Orthologs:
Mus musculus (house mouse) : Plau (plasminogen activator, urokinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plau (plasminogen activator, urokinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plau (plasminogen activator, urokinase)
Pan paniscus (bonobo/pygmy chimpanzee) : PLAU (plasminogen activator, urokinase)
Canis lupus familiaris (dog) : PLAU (plasminogen activator, urokinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plau (plasminogen activator, urokinase)
Sus scrofa (pig) : PLAU (plasminogen activator, urokinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381073,909,182 - 73,917,501 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371075,670,862 - 75,677,259 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361075,340,896 - 75,347,261 (+)NCBINCBI36hg18NCBI36
Build 341075,340,895 - 75,347,260NCBI
Celera1068,954,178 - 68,960,575 (+)NCBI
Cytogenetic Map10q22.2NCBI
HuRef1069,665,797 - 69,672,195 (+)NCBIHuRef
CHM1_11075,952,621 - 75,959,021 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PLAU
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735727
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.