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Gene: PLAU (plasminogen activator, urokinase) Homo sapiens
Symbol: PLAU
Name: plasminogen activator, urokinase
Description: Predicted to have serine-type endopeptidase activity. Involved in several processes, including plasminogen activation; regulation of cell migration; and regulation of smooth muscle cell-matrix adhesion. Localizes to the cell surface and extracellular space. Implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal failure; lung disease (multiple); and mitral valve prolapse. Biomarker of several diseases, including appendicitis; carcinoma (multiple); chronic obstructive pulmonary disease; end stage renal failure; and hepatitis B.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATF; BDPLT5; plasminogen activator, urinary; QPD; u-PA; U-plasminogen activator; UPA; URK; urokinase-type plasminogen activator
Mus musculus (house mouse) : Plau (plasminogen activator, urokinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plau (plasminogen activator, urokinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plau (plasminogen activator, urokinase)
Pan paniscus (bonobo/pygmy chimpanzee) : PLAU (plasminogen activator, urokinase)
Canis lupus familiaris (dog) : PLAU (plasminogen activator, urokinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plau (plasminogen activator, urokinase)
Sus scrofa (pig) : PLAU (plasminogen activator, urokinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381073,909,182 - 73,917,501 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371075,670,862 - 75,677,259 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361075,340,896 - 75,347,261 (+)NCBINCBI36hg18NCBI36
Build 341075,340,895 - 75,347,260NCBI
Celera1068,954,178 - 68,960,575 (+)NCBI
Cytogenetic Map10q22.2NCBI
HuRef1069,665,797 - 69,672,195 (+)NCBIHuRef
CHM1_11075,952,621 - 75,959,021 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PLAU
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735727
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.