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Gene: FOS (Fos proto-oncogene, AP-1 transcription factor subunit) Homo sapiens
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Symbol: FOS
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Description: Exhibits several functions, including R-SMAD binding activity; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II core promoter sequence-specific DNA binding activity. Involved in several processes, including cellular response to cadmium ion; cellular response to reactive oxygen species; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to the nucleoplasm; protein-DNA complex; and transcription factor AP-1 complex. Biomarker of Pick's disease; autosomal dominant polycystic kidney disease; cervical squamous cell carcinoma; colorectal adenocarcinoma; and intestinal benign neoplasm (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activator protein 1; AP-1; C-FOS; cellular oncogene c-fos; cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; Fos proto-oncogene, AP-1 trancription factor subunit; G0/G1 switch regulatory protein 7; p55; proto-oncogene c-Fos; v-fos FBJ murine osteosarcoma viral oncogene homolog
Orthologs:
Mus musculus (house mouse) : Fos (FBJ osteosarcoma oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fos (Fos proto-oncogene, AP-1 transcription factor subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fos (Fos proto-oncogene, AP-1 transcription factor subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : FOS (Fos proto-oncogene, AP-1 transcription factor subunit)
Canis lupus familiaris (dog) : FOS (Fos proto-oncogene, AP-1 transcription factor subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fos (Fos proto-oncogene, AP-1 transcription factor subunit)
Sus scrofa (pig) : FOS (Fos proto-oncogene, AP-1 transcription factor subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1475,278,826 - 75,282,230 (+)Ensembl
GRCh381475,278,828 - 75,282,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371475,745,477 - 75,748,937 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,815,284 - 74,818,666 (+)NCBINCBI36hg18NCBI36
Build 341474,815,283 - 74,818,666NCBI
Celera1455,783,567 - 55,787,023 (+)NCBI
Cytogenetic Map14q24.3NCBI
HuRef1455,913,924 - 55,917,380 (+)NCBIHuRef
CHM1_11475,683,266 - 75,686,721 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations