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Gene: Lef1 (lymphoid enhancer binding factor 1) Mus musculus
Symbol: Lef1
Name: lymphoid enhancer binding factor 1
Description: Exhibits several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including animal organ development; blood vessel morphogenesis; and regulation of transcription by RNA polymerase II. Localizes to the cytoplasm; nucleus; and transcription factor complex. Human ortholog(s) of this gene implicated in ovarian cancer. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and integumental system. Orthologous to human LEF1 (lymphoid enhancer binding factor 1); PARTICIPATES IN Wnt signaling, canonical pathway; acute myeloid leukemia pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH 1,2-dibromoethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3000002B05; AI451430; Lef-1; lymphoid enhancer factor 1; lymphoid enhancer-binding factor 1
Homo sapiens (human) : LEF1 (lymphoid enhancer binding factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lef1 (lymphoid enhancer binding factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lef1 (lymphoid enhancer binding factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LEF1 (lymphoid enhancer binding factor 1)
Canis lupus familiaris (dog) : LEF1 (lymphoid enhancer binding factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lef1 (lymphoid enhancer binding factor 1)
Sus scrofa (pig) : LEF1 (lymphoid enhancer binding factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm383131,110,277 - 131,224,357 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv373130,813,389 - 130,926,252 (+)NCBIGRCm37mm9NCBIm37
MGSCv363131,099,626 - 131,212,489 (+)NCBImm8
Celera3137,629,833 - 137,745,477 (+)NCBICelera
Cytogenetic Map3 G3NCBI
cM Map360.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lef1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735737
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.