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Gene: Lef1 (lymphoid enhancer binding factor 1) Mus musculus
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Symbol: Lef1
Name: lymphoid enhancer binding factor 1
Description: Exhibits several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including animal organ development; blood vessel morphogenesis; and regulation of transcription by RNA polymerase II. Localizes to the cytoplasm; nucleus; and transcription factor complex. Human ortholog(s) of this gene implicated in ovarian cancer. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and integumental system. Orthologous to human LEF1 (lymphoid enhancer binding factor 1); PARTICIPATES IN Wnt signaling, canonical pathway; acute myeloid leukemia pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH 1,2-dibromoethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3000002B05; AI451430; Lef-1; lymphoid enhancer factor 1; lymphoid enhancer-binding factor 1
Orthologs:
Homo sapiens (human) : LEF1 (lymphoid enhancer binding factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lef1 (lymphoid enhancer binding factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lef1 (lymphoid enhancer binding factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LEF1 (lymphoid enhancer binding factor 1)
Canis lupus familiaris (dog) : LEF1 (lymphoid enhancer binding factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lef1 (lymphoid enhancer binding factor 1)
Sus scrofa (pig) : LEF1 (lymphoid enhancer binding factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm383131,110,277 - 131,224,357 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv373130,813,389 - 130,926,252 (+)NCBIGRCm37mm9NCBIm37
MGSCv363131,099,626 - 131,212,489 (+)NCBImm8
Celera3137,629,833 - 137,745,477 (+)NCBICelera
Cytogenetic Map3 G3NCBI
cM Map360.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Lef1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735737
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.