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Gene: Runx2 (runt related transcription factor 2) Mus musculus
Symbol: Runx2
Name: runt related transcription factor 2
CRRD ID: 735753
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of cell differentiation; regulation of transcription, DNA-templated; and skeletal system development. Localizes to cytoplasm; nuclear chromatin; and transcription regulator complex. Is expressed in several structures, including alimentary system; genitourinary system; limb mesenchyme; sensory organ; and skeleton. Used to study cleidocranial dysplasia and congenital hypothyroidism. Human ortholog(s) of this gene implicated in cleidocranial dysplasia and metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome. Orthologous to human RUNX2 (RUNX family transcription factor 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acute myeloid leukemia 3 protein; AKV core binding factor; AM; AML3; Cbf; CBF-alpha-1; Cbfa; Cbfa-1; Cbfa1; core binding factor alpha 1; LS3; Os; Osf2; osteoblast-specific transcription factor 2; PEA2-alpha A; PEB; PEBP2 alpha A; Pebp2a1; PEBP2aA; Pebpa2a; polyomavirus enhancer-binding protein 2 alpha A subunit; runt domain, alpha subunit 1; runt-related transcription factor 2; SL3-3 enhancer factor 1 alpha A subunit; transcription factor Cbfa1/Osf2
Homo sapiens (human) : RUNX2 (RUNX family transcription factor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Runx2 (RUNX family transcription factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Runx2 (RUNX family transcription factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RUNX2 (RUNX family transcription factor 2)
Canis lupus familiaris (dog) : RUNX2 (RUNX family transcription factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Runx2 (RUNX family transcription factor 2)
Sus scrofa (pig) : RUNX2 (RUNX family transcription factor 2)
Chlorocebus sabaeus (African green monkey) : RUNX2 (RUNX family transcription factor 2)
Heterocephalus glaber (naked mole-rat) : Runx2 (RUNX family transcription factor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391744,806,874 - 45,125,684 (-)NCBI
GRCm381744,495,987 - 44,814,797 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1744,495,987 - 44,814,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv371744,740,950 - 44,951,746 (-)NCBIGRCm37mm9NCBIm37
MGSCv361744,067,056 - 44,277,682 (-)NCBImm8
Celera1748,040,272 - 48,252,046 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1721.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Runx2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735753
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.