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Gene: Runx2 (runt related transcription factor 2) Mus musculus
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Symbol: Runx2
Name: runt related transcription factor 2
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in several processes, including positive regulation of cell differentiation; regulation of transcription, DNA-templated; and skeletal system development. Localizes to the cytoplasm; nuclear chromatin; and transcription factor complex. Used to study cleidocranial dysplasia and congenital hypothyroidism. Human ortholog(s) of this gene implicated in cleidocranial dysplasia. Is expressed in several structures, including genitourinary system; jaw; limb mesenchyme; sensory organ; and skeleton. Orthologous to human RUNX2 (RUNX family transcription factor 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acute myeloid leukemia 3 protein; AKV core binding factor; AML3; Cbf; CBF-alpha-1; Cbfa-1; Cbfa1; core binding factor alpha 1; LS3; Osf2; osteoblast-specific transcription factor 2; PEA2-alpha A; PEBP2 alpha A; Pebp2a1; PEBP2aA; Pebpa2a; polyomavirus enhancer-binding protein 2 alpha A subunit; runt domain, alpha subunit 1; runt-related transcription factor 2; SL3-3 enhancer factor 1 alpha A subunit
Orthologs:
Homo sapiens (human) : RUNX2 (RUNX family transcription factor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Runx2 (RUNX family transcription factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Runx2 (RUNX family transcription factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RUNX2 (RUNX family transcription factor 2)
Canis lupus familiaris (dog) : RUNX2 (RUNX family transcription factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Runx2 (RUNX family transcription factor 2)
Sus scrofa (pig) : RUNX2 (RUNX family transcription factor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381744,495,987 - 44,814,797 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371744,740,950 - 44,951,746 (-)NCBIGRCm37mm9NCBIm37
MGSCv361744,067,056 - 44,277,682 (-)NCBImm8
Celera1747,933,342 - 48,252,046 (-)NCBICelera
Cytogenetic Map17 B3NCBI
cM Map1721.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Runx2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735753
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.