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Gene: SFRP1 (secreted frizzled related protein 1) Homo sapiens
Symbol: SFRP1
Name: secreted frizzled related protein 1
Description: Exhibits several functions, including Wnt-protein binding activity; frizzled binding activity; and heparin binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to lipid; and regulation of signal transduction. Localizes to several cellular components, including the cell surface; collagen-containing extracellular matrix; and extracellular space. Biomarker of in situ carcinoma; leiomyoma; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FRP; FRP-1; FRP1; FrzA; SARP-2; SARP2; secreted apoptosis-related protein 2; secreted frizzled-related protein 1; sFRP-1
Mus musculus (house mouse) : Sfrp1 (secreted frizzled-related protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sfrp1 (secreted frizzled-related protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sfrp1 (secreted frizzled related protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SFRP1 (secreted frizzled related protein 1)
Canis lupus familiaris (dog) : SFRP1 (secreted frizzled related protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sfrp1 (secreted frizzled related protein 1)
Sus scrofa (pig) : SFRP1 (secreted frizzled related protein 1)
Chlorocebus sabaeus (African green monkey) : SFRP1 (secreted frizzled related protein 1)
Heterocephalus glaber (naked mole-rat) : Sfrp1 (secreted frizzled related protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl841,261,962 - 41,309,473 (-)EnsemblGRCh38hg38GRCh38
GRCh38841,261,962 - 41,309,473 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37841,119,476 - 41,166,990 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36841,238,635 - 41,286,137 (-)NCBINCBI36hg18NCBI36
Build 34841,238,635 - 41,286,137NCBI
Celera840,068,517 - 40,116,053 (-)NCBI
Cytogenetic Map8p11.21NCBI
HuRef839,647,919 - 39,695,566 (-)NCBIHuRef
CHM1_1841,167,412 - 41,215,102 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SFRP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735754
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.