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Gene: ATF3 (activating transcription factor 3) Homo sapiens
Symbol: ATF3
Name: activating transcription factor 3
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of TRAIL-activated apoptotic signaling pathway; and positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress. Localizes to CHOP-ATF3 complex; nucleolus; and nucleoplasm. Biomarker of prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATF3deltaZip2; ATF3deltaZip2c; ATF3deltaZip3; cAMP-dependent transcription factor ATF-3; cyclic AMP-dependent transcription factor ATF-3; FLJ41705
Mus musculus (house mouse) : Atf3 (activating transcription factor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Atf3 (activating transcription factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atf3 (activating transcription factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ATF3 (activating transcription factor 3)
Canis lupus familiaris (dog) : ATF3 (activating transcription factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atf3 (activating transcription factor 3)
Sus scrofa (pig) : ATF3 (activating transcription factor 3)
Chlorocebus sabaeus (African green monkey) : ATF3 (activating transcription factor 3)
Heterocephalus glaber (naked mole-rat) : Atf3 (activating transcription factor 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1212,565,334 - 212,620,777 (+)EnsemblGRCh38hg38GRCh38
GRCh381212,565,334 - 212,620,777 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371212,738,676 - 212,794,119 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,805,320 - 210,860,740 (+)NCBINCBI36hg18NCBI36
Build 341209,170,507 - 209,182,494NCBI
Celera1185,964,759 - 186,020,178 (+)NCBI
Cytogenetic Map1q32.3NCBI
HuRef1183,415,472 - 183,470,943 (+)NCBIHuRef
CHM1_11214,011,558 - 214,066,986 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ATF3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735760
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.