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Gene: Scn1a (sodium channel, voltage-gated, type I, alpha) Mus musculus
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Symbol: Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Description: Exhibits voltage-gated sodium channel activity. Involved in several processes, including adult walking behavior; detection of mechanical stimulus involved in sensory perception of pain; and neuronal action potential. Localizes to several cellular components, including the T-tubule; Z disc; and main axon. Used to study Dravet syndrome; autism spectrum disorder; and generalized epilepsy with febrile seizures plus. Human ortholog(s) of this gene implicated in Dravet syndrome; familial hemiplegic migraine 3; generalized epilepsy with febrile seizures plus; and generalized epilepsy with febrile seizures plus 2. Is expressed in brain; heart; sciatic nerve; sympathetic ganglion; and telencephalon. Orthologous to human SCN1A (sodium voltage-gated channel alpha subunit 1); INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B230332M13; Nav1.1; sodium channel protein brain I subunit alpha; sodium channel protein type 1 subunit alpha; sodium channel protein type I subunit alpha; voltage-gated sodium channel subunit alpha Nav1.1
Orthologs:
Homo sapiens (human) : SCN1A (sodium voltage-gated channel alpha subunit 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Scn1a (sodium voltage-gated channel alpha subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Scn1a (sodium voltage-gated channel alpha subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SCN1A (sodium voltage-gated channel alpha subunit 1)
Canis lupus familiaris (dog) : SCN1A (sodium voltage-gated channel alpha subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scn1a (sodium voltage-gated channel alpha subunit 1)
Sus scrofa (pig) : SCN1A (sodium voltage-gated channel alpha subunit 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl266,270,778 - 66,440,840 (-)Ensembl
GRCm38266,270,781 - 66,440,837 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37266,108,839 - 66,278,894 (-)NCBIGRCm37mm9NCBIm37
MGSCv36266,071,621 - 66,241,676 (-)NCBImm8
Celera267,950,131 - 68,119,920 (-)NCBICelera
Cytogenetic Map2 C1.3NCBI
cM Map239.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Scn1a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735778
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.